The Effects of Exercise-Associated Factors on Hippocampal Progenitor Cell Dynamics Are Mediated by Cannabinoid Type 2 Receptors

Rodrigues RS, Moreira JB, Dias P, Sebastião AM, Xapelli S. J Neurochem. 2025 May;169(5):e70091. doi: 10.1111/jnc.70091.

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Cleavage of the TrkB-FL receptor during epileptogenesis: insights from a kainic acid-induced model of epilepsy and human samples

Ribeiro-Rodrigues L, Fonseca-Gomes J, Paulo SL, Viais R, Ribeiro FF, Miranda-Lourenço C, Mouro FM, Belo RF, Ferreira CB, Tanqueiro SR, Ferreira-Manso M, Umemori J, Castrén E, Paiva VH, Sebastião AM, Aronica E, Campos AR, Bentes C, Xapelli S, Diógenes MJ. Pharmacol Res. 2025 May; 215:107707. doi: 10.1016/j.phrs.2025.107707.

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Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug

Ghosh A, Ribeiro-Rodrigues L, Ruffolo G, Alfano V, Domingos C, Rei N, Tosh DK, Rombo DM, Morais TP, Valente CA, Xapelli S, Bordadágua B, Rainha-Campos A, Bentes C, Aronica E, Diógenes MJ, Vaz SH, Ribeiro JA, Palma E, Jacobson KA, Sebastião AM. Br J Pharmacol. 2024 Dec;181(24):5041-5061. doi: 10.1111/bph.17319.

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Lineage-specific changes in mitochondrial properties during neural stem cell differentiation

Soares R, Lourenço DM, Mota IF, Sebastião AM, Xapelli S, Morais VA. Life Sci Alliance. 2024 Apr 25;7(7):e202302473. doi: 10.26508/lsa.202302473. 

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Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress

Rodrigues RS, Moreira JB, Mateus JM, Barateiro A, Paulo SL, Vaz SH, Lourenço DM, Ribeiro FF, Soares R, Loureiro-Campos E, Bielefeld P, Sebastião AM, Fernandes A, Pinto L, Fitzsimons CP, Xapelli S. Transl Psychiatry. 2024 Mar 30;14(1):170. doi: 10.1038/s41398-024-02877-0. 

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Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration

Nunes MJ, Carvalho AN, Reis J, Costa D, Moutinho M, Mateus J, Mendes de Almeida R, Brito S, Risso D, Nunes S, Castro-Caldas M, Gama MJ, Rodrigues CMP, Xapelli S, Diógenes MJ, Cartier N, Chali F, Piguet F, Rodrigues E. Biochim Biophys Acta Mol Basis Dis. 2023 Dec 22;1870(3):166993. doi: 10.1016/j.bbadis.2023.166993. 

 

Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

Lourenço DM, Soares R, Sá-Santos S, Mateus JM, Rodrigues RS, Moreira JB, Vaz SH, Sebastião AM, Solá S, Xapelli S. Eur J Pharmacol. 2023 Nov 15;959:176079. doi: 10.1016/j.ejphar.2023.176079. 

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S100B inhibition protects from chronic experimental autoimmune encephalomyelitis

Barros C, Barateiro A, Neto A, Soromenho B, Basto AP, Mateus JM, Xapelli S, Sebastião AM, Brites D, Graça L, Fernandes A.Brain Commun. 2022 Mar 25;4(3):fcac076. doi: 10.1093/braincomms/fcac076. eCollection 2022.

 

The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression

Santos SS, Moreira JB, Costa M, Rodrigues RS, Sebastião AM, Xapelli S, Solá S.Cells. 2021 Dec 29;11(1):90. doi: 10.3390/cells11010090.

 

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats

Paulo SL, Miranda-Lourenço C, Belo RF, Rodrigues RS, Fonseca-Gomes J, Tanqueiro SR, Geraldes V, Rocha I, Sebastião AM, Xapelli S, Diógenes MJ.Curr Issues Mol Biol. 2021 Dec 18;43(3):2305-2319. doi: 10.3390/cimb43030162.

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Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer's Disease Model

Paulo SL, Ribeiro-Rodrigues L, Rodrigues RS, Mateus JM, Fonseca-Gomes J, Soares R, Diógenes MJ, Solá S, Sebastião AM, Ribeiro FF, Xapelli S.J Alzheimers Dis. 2021;82(3):1183-1202. doi: 10.3233/JAD-201567.

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Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

Ribeiro FF, Ferreira F, Rodrigues RS, Soares R, Pedro DM, Duarte-Samartinho M, Aroeira RI, Ferreiro E, Valero J, Solá S, Mira H, Sebastião AM, Xapelli S.Stem Cells. 2021 Oct;39(10):1362-1381. doi: 10.1002/stem.3421.

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Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus

Viana MB, Martins RS, Silva MSCF, Xapelli S, Vaz SH, Sebastião AM.Behav Brain Res. 2021 Apr 9;403:113134. doi: 10.1016/j.bbr.2021.113134.

 

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Gomes AR, Fernandes TG, Vaz SH, Silva TP, Bekman EP, Xapelli S, Duarte S, Ghazvini M, Gribnau J, Muotri AR, Trujillo CA, Sebastião AM, Cabral JMS, Diogo MM.Front Cell Dev Biol. 2020 Dec 10;8:610427. doi: 10.3389/fcell.2020.610427.

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Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Miranda-Lourenço C, Duarte ST, Palminha C, Gaspar C, Rodrigues TM, Magalhães-Cardoso T, Rei N, Colino-Oliveira M, Gomes R, Ferreira S, Rosa J, Xapelli S, Armstrong J, García-Cazorla À, Correia-de-Sá P, Sebastião AM, Diógenes MJ.Neurobiol Dis. 2020 Nov;145:105043. doi: 10.1016/j.nbd.2020.105043. 

 

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology

Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.Front Pharmacol. 2020 Jul 9;11:985. doi: 10.3389/fphar.2020.00985.

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Isolation and Expansion of Neurospheres from Postnatal (P1-3) Mouse Neurogenic Niches

Soares R, Ribeiro FF, Lourenço DM, Rodrigues RS, Moreira JB, Sebastião AM, Morais VA, Xapelli S.J Vis Exp. 2020 May 23;(159). doi: 10.3791/60822.

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Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis

Ferreira FF, Ribeiro FF, Rodrigues RS, Sebastião AM, Xapelli S.Front Cell Neurosci. 2018 Nov 28;12:441. doi: 10.3389/fncel.2018.00441.

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Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis

Rodrigues RS, Ribeiro FF, Ferreira F, Vaz SH, Sebastião AM, Xapelli S.Front Pharmacol. 2017 Aug 10;8:516. doi: 10.3389/fphar.2017.00516.

 

Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats

Soares R, Ribeiro FF, Xapelli S, Genebra T, Ribeiro MF, Sebastião AM, Rodrigues CMP, Solá S.Mol Neurobiol. 2018 May; 55(5):3725-3738. doi: 10.1007/s12035-017-0592-5.​