Original work:

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress.

Rodrigues RS, Moreira JB, Mateus JM, Barateiro A, Paulo SL, Vaz SH, Lourenço DM, Ribeiro FF, Soares R, Loureiro-Campos E, Bielefeld P, Sebastião AM, Fernandes A, Pinto L, Fitzsimons CP, Xapelli S. Transl Psychiatry. 2024 Mar 30;14(1):170. doi: 10.1038/s41398-024-02877-0. 

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Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration.

Nunes MJ, Carvalho AN, Reis J, Costa D, Moutinho M, Mateus J, Mendes de Almeida R, Brito S, Risso D, Nunes S, Castro-Caldas M, Gama MJ, Rodrigues CMP, Xapelli S, Diógenes MJ, Cartier N, Chali F, Piguet F, Rodrigues E. Biochim Biophys Acta Mol Basis Dis. 2023 Dec 22;1870(3):166993. doi: 10.1016/j.bbadis.2023.166993. 

 

Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis.

Lourenço DM, Soares R, Sá-Santos S, Mateus JM, Rodrigues RS, Moreira JB, Vaz SH, Sebastião AM, Solá S, Xapelli S. Eur J Pharmacol. 2023 Nov 15;959:176079. doi: 10.1016/j.ejphar.2023.176079. 

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S100B inhibition protects from chronic experimental autoimmune encephalomyelitis.

Barros C, Barateiro A, Neto A, Soromenho B, Basto AP, Mateus JM, Xapelli S, Sebastião AM, Brites D, Graça L, Fernandes A.Brain Commun. 2022 Mar 25;4(3):fcac076. doi: 10.1093/braincomms/fcac076. eCollection 2022.

 

The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression.

Santos SS, Moreira JB, Costa M, Rodrigues RS, Sebastião AM, Xapelli S, Solá S.Cells. 2021 Dec 29;11(1):90. doi: 10.3390/cells11010090.

 

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.

Paulo SL, Miranda-Lourenço C, Belo RF, Rodrigues RS, Fonseca-Gomes J, Tanqueiro SR, Geraldes V, Rocha I, Sebastião AM, Xapelli S, Diógenes MJ.Curr Issues Mol Biol. 2021 Dec 18;43(3):2305-2319. doi: 10.3390/cimb43030162.

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Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer's Disease Model.

Paulo SL, Ribeiro-Rodrigues L, Rodrigues RS, Mateus JM, Fonseca-Gomes J, Soares R, Diógenes MJ, Solá S, Sebastião AM, Ribeiro FF, Xapelli S.J Alzheimers Dis. 2021;82(3):1183-1202. doi: 10.3233/JAD-201567.

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Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor.

Ribeiro FF, Ferreira F, Rodrigues RS, Soares R, Pedro DM, Duarte-Samartinho M, Aroeira RI, Ferreiro E, Valero J, Solá S, Mira H, Sebastião AM, Xapelli S.Stem Cells. 2021 Oct;39(10):1362-1381. doi: 10.1002/stem.3421. Epub 2021 Jun 7.PMID: 34043863 Free article.

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Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus.

Viana MB, Martins RS, Silva MSCF, Xapelli S, Vaz SH, Sebastião AM.Behav Brain Res. 2021 Apr 9;403:113134. doi: 10.1016/j.bbr.2021.113134. Epub 2021 Jan 18.

 

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids.

Gomes AR, Fernandes TG, Vaz SH, Silva TP, Bekman EP, Xapelli S, Duarte S, Ghazvini M, Gribnau J, Muotri AR, Trujillo CA, Sebastião AM, Cabral JMS, Diogo MM.Front Cell Dev Biol. 2020 Dec 10;8:610427. doi: 10.3389/fcell.2020.610427. eCollection 2020.

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Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling.

Miranda-Lourenço C, Duarte ST, Palminha C, Gaspar C, Rodrigues TM, Magalhães-Cardoso T, Rei N, Colino-Oliveira M, Gomes R, Ferreira S, Rosa J, Xapelli S, Armstrong J, García-Cazorla À, Correia-de-Sá P, Sebastião AM, Diógenes MJ.Neurobiol Dis. 2020 Nov;145:105043. doi: 10.1016/j.nbd.2020.105043. 

 

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.Front Pharmacol. 2020 Jul 9;11:985. doi: 10.3389/fphar.2020.00985. eCollection 2020.

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Isolation and Expansion of Neurospheres from Postnatal (P1-3) Mouse Neurogenic Niches.

Soares R, Ribeiro FF, Lourenço DM, Rodrigues RS, Moreira JB, Sebastião AM, Morais VA, Xapelli S.J Vis Exp. 2020 May 23;(159). doi: 10.3791/60822.

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Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis.

Ferreira FF, Ribeiro FF, Rodrigues RS, Sebastião AM, Xapelli S.Front Cell Neurosci. 2018 Nov 28;12:441. doi: 10.3389/fncel.2018.00441. eCollection 2018.

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Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis.

Rodrigues RS, Ribeiro FF, Ferreira F, Vaz SH, Sebastião AM, Xapelli S.Front Pharmacol. 2017 Aug 10;8:516. doi: 10.3389/fphar.2017.00516. eCollection 2017.

 

Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats.

Soares R, Ribeiro FF, Xapelli S, Genebra T, Ribeiro MF, Sebastião AM, Rodrigues CMP, Solá S.Mol Neurobiol. 2018 May;55(5):3725-3738. doi: 10.1007/s12035-017-0592-5. Epub 2017 May 22.

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Reviews:

Role of purines in brain development, from neuronal proliferation to synaptic refinement.

Rimbert S, Moreira JB, Xapelli S, Lévi S. Neuropharmacology. 2023 Jun 20;237:109640. doi: 10.1016/j.neuropharm.2023.109640. 

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Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions.

Latta L, Figueiredo FC, Ashery-Padan R, Collinson JM, Daniels J, Ferrari S, Szentmáry N, Solá S, Shalom-Feuerstein R, Lako M, Xapelli S, Aberdam D, Lagali N.Ocul Surf. 2021 Oct;22:245-266. doi: 10.1016/j.jtos.2021.09.001.

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The neurosphere assay: an effective in vitro technique to study neural stem cells.

Soares R, Ribeiro FF, Lourenço DM, Rodrigues RS, Moreira JB, Sebastião AM, Morais VA, Xapelli S.Neural Regen Res. 2021 Nov;16(11):2229-2231. doi: 10.4103/1673-5374.310678.

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Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy.

Lourenço DM, Ribeiro-Rodrigues L, Sebastião AM, Diógenes MJ, Xapelli S.Int J Mol Sci. 2020 Oct 3;21(19):7309. doi: 10.3390/ijms21197309.P

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Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders.

Rodrigues RS, Paulo SL, Moreira JB, Tanqueiro SR, Sebastião AM, Diógenes MJ, Xapelli S.Stem Cells Dev. 2020 Sep 1;29(17):1099-1117. doi: 10.1089/scd.2020.0100.

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​Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology.

Rodrigues RS, Lourenço DM, Paulo SL, Mateus JM, Ferreira MF, Mouro FM, Moreira JB, Ribeiro FF, Sebastião AM, Xapelli S.Molecules. 2019 Apr 5;24(7):1350. doi: 10.3390/molecules24071350.PMID: 30959794 Review.

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Interventions for age-related diseases: Shifting the paradigm.

Figueira I, Fernandes A, Mladenovic Djordjevic A, Lopez-Contreras A, Henriques CM, Selman C, Ferreiro E, Gonos ES, Trejo JL, Misra J, Rasmussen LJ, Xapelli S, Ellam T, Bellantuono I.Mech Ageing Dev. 2016 Dec;160:69-92. doi: 10.1016/j.mad.2016.09.009. 

 

Purine nucleosides in neuroregeneration and neuroprotection.

Ribeiro FF, Xapelli S, Miranda-Lourenço C, Tanqueiro SR, Fonseca-Gomes J, Diógenes MJ, Ribeiro JA, Sebastião AM.Neuropharmacology. 2016 May;104:226-42. doi: 10.1016/j.neuropharm.2015.11.006. 

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Book Chapters:

Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis.

Ribeiro FF, Xapelli S.Adv Exp Med Biol. 2021;1331:95-115. doi: 10.1007/978-3-030-74046-7_8.

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An Overview of Adult Neurogenesis.

Ribeiro FF, Xapelli S.Adv Exp Med Biol. 2021;1331:77-94. doi: 10.1007/978-3-030-74046-7_7.